Semax – 5mg

Description

Primary Uses of Semax

1. Cognitive Enhancement (Nootropic):
   • Semax boosts brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus, enhancing memory, learning, and focus. Animal studies show rapid increases in BDNF levels post-administration, supporting neuroplasticity.
   • In a 1996 Russian study, healthy workers given 250-1000 µg intranasally showed improved attention and short-term memory, especially under fatigue, with effects lasting into the next day.
2. Stroke Recovery and Neuroprotection:
   • Approved in Russia for ischemic stroke, Semax accelerates recovery of motor and cognitive functions. A 2018 trial with 110 stroke patients found it increased plasma BDNF, aiding rehabilitation.
   • It protects neurons from oxidative stress and stabilizes mitochondria, reducing damage during hypoxia (low oxygen), as seen in rat models of cerebral ischemia.
3. Anxiety and Mood Regulation:
   • Semax exhibits anxiolytic (anti-anxiety) and antidepressant-like effects in animal studies, normalizing behavior under stress by activating serotonergic and dopaminergic systems. It doesn’t sedate, unlike benzodiazepines.
   • It inhibits enkephalinases, preserving enkephalins (natural pain and mood regulators), potentially enhancing emotional resilience.
4. Other Conditions:
   • Optic Nerve Disease: Russian studies (e.g., Polunin et al., 2000) report improved outcomes in optic neuropathy.
   • ADHD and Depression: Suggested as a potential treatment due to its neurotransmitter effects, though human data is limited.
   • Immune Boost: May enhance immune response via gene expression changes, per preclinical research.

How It Works

• BDNF and Neuroplasticity: Upregulates BDNF and NGF (nerve growth factor), promoting neuron growth and adaptability.
• Neurotransmitter Modulation: Increases dopamine and serotonin activity, enhancing mood and cognition.
• Gene Expression: In rat studies, Semax altered expression of genes tied to immune response (e.g., immunoglobulins) and vascular function (e.g., angiogenesis), suggesting systemic protective effects during ischemia.
• Copper Binding: Research (Sciacca et al., 2022) shows Semax binds Cu2+, potentially reducing amyloid-beta aggregation in Alzheimer’s models.

How It’s Used

• Administration: Primarily intranasal (nasal spray) due to poor oral bioavailability—peptides break down in the stomach. Subcutaneous injections are less common.
• Dosage: Typically 250-1000 µg/day intranasally (e.g., 1-2 sprays per nostril), often in cycles (e.g., 10-14 days). Doses vary by goal—consultation is key.

Product Usage: This item is designed exclusively for use as a research chemical in laboratory settings and in vitro experiments, to be handled only by licensed, trained professionals. It is not intended or approved for human or animal consumption. Any misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly forbidden. All accompanying information is provided solely for educational purposes.